The Calsequestrin Mutation CASQ2(D307H) Does Not Affect Protein Stability and Targeting to the Junctional Sarcoplasmic Reticulum but Compromises Its Dynamic Regulation of Calcium Buffering

Mutations in cardiac ryanodine receptor (RYR2) and cardiac calsequestrin (CASQ2) genes are linked to catecholaminergic polymorphic ventricular tachycardia, a life-threatening genetic disease. They predispose young individuals to cardiac arrhythmia in the absence of structural abnormalities. One such...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Kalyanasundaram, Anuradha, Bal, Naresh C., Franzini-Armstrong, Clara, Knollmann, Björn C., Periasamy, Muthu
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Protein Synthesis, Post-Translational Modification, and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2823443/
https://ncbi.nlm.nih.gov/pubmed/19920148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.053892
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky