The Calsequestrin Mutation CASQ2(D307H) Does Not Affect Protein Stability and Targeting to the Junctional Sarcoplasmic Reticulum but Compromises Its Dynamic Regulation of Calcium Buffering

Mutations in cardiac ryanodine receptor (RYR2) and cardiac calsequestrin (CASQ2) genes are linked to catecholaminergic polymorphic ventricular tachycardia, a life-threatening genetic disease. They predispose young individuals to cardiac arrhythmia in the absence of structural abnormalities. One such...

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Bibliographic Details
Main Authors:	Kalyanasundaram, Anuradha, Bal, Naresh C., Franzini-Armstrong, Clara, Knollmann, Björn C., Periasamy, Muthu
Format:	Artigo
Language:	Inglês
Published:	American Society for Biochemistry and Molecular Biology 2010
Subjects:	Protein Synthesis, Post-Translational Modification, and Degradation
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2823443/ https://ncbi.nlm.nih.gov/pubmed/19920148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.053892
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The Calsequestrin Mutation CASQ2(D307H) Does Not Affect Protein Stability and Targeting to the Junctional Sarcoplasmic Reticulum but Compromises Its Dynamic Regulation of Calcium Buffering

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