Modulation of SR Ca Release by Luminal Ca and Calsequestrin in Cardiac Myocytes: Effects of CASQ2 Mutations Linked to Sudden Cardiac Death

Cardiac calsequestrin (CASQ2) is an intrasarcoplasmic reticulum (SR) low-affinity Ca-binding protein, with mutations that are associated with catecholamine-induced polymorphic ventricular tachycardia (CPVT). To better understand how CASQ2 mutants cause CPVT, we expressed two CPVT-linked CASQ2 mutant...

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Detalhes bibliográficos
Main Authors: Terentyev, Dmitry, Kubalova, Zuzana, Valle, Giorgia, Nori, Alessandra, Vedamoorthyrao, Srikanth, Terentyeva, Radmila, Viatchenko-Karpinski, Serge, Bers, Donald M., Williams, Simon C., Volpe, Pompeo, Gyorke, Sandor
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2008
Assuntos:
Cell Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2483765/
https://ncbi.nlm.nih.gov/pubmed/18469084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.128249
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