Neuronal Na(+) Channels Are Integral Components of Pro-Arrhythmic Na(+)/Ca(2+) Signaling Nanodomain That Promotes Cardiac Arrhythmias During β-Adrenergic Stimulation

Although triggered arrhythmias including catecholaminergic polymorphic ventricular tachycardia (CPVT) are often caused by increased levels of circulating catecholamines, the mechanistic link between β-adrenergic receptor (AR) stimulation and the subcellular/molecular arrhythmogenic trigger(s) is unc...

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Detalhes bibliográficos
Publicado no:JACC Basic Transl Sci
Main Authors: Radwański, Przemysław B., Ho, Hsiang-Ting, Veeraraghavan, Rengasayee, Brunello, Lucia, Liu, Bin, Belevych, Andriy E., Unudurthi, Sathya D., Makara, Michael A., Priori, Silvia G., Volpe, Pompeo, Armoundas, Antonis A., Dillmann, Wolfgang H., Knollmann, Bjorn C., Mohler, Peter J., Hund, Thomas J., Györke, Sándor
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
Assuntos:
PRE-CLINICAL RESEARCH
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065245/
https://ncbi.nlm.nih.gov/pubmed/27747307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2016.04.004
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