Neuronal Na(+) Channels Are Integral Components of Pro-Arrhythmic Na(+)/Ca(2+) Signaling Nanodomain That Promotes Cardiac Arrhythmias During β-Adrenergic Stimulation

Although triggered arrhythmias including catecholaminergic polymorphic ventricular tachycardia (CPVT) are often caused by increased levels of circulating catecholamines, the mechanistic link between β-adrenergic receptor (AR) stimulation and the subcellular/molecular arrhythmogenic trigger(s) is unc...

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Udgivet i:JACC Basic Transl Sci
Main Authors: Radwański, Przemysław B., Ho, Hsiang-Ting, Veeraraghavan, Rengasayee, Brunello, Lucia, Liu, Bin, Belevych, Andriy E., Unudurthi, Sathya D., Makara, Michael A., Priori, Silvia G., Volpe, Pompeo, Armoundas, Antonis A., Dillmann, Wolfgang H., Knollmann, Bjorn C., Mohler, Peter J., Hund, Thomas J., Györke, Sándor
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016
Fag:
PRE-CLINICAL RESEARCH
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065245/
https://ncbi.nlm.nih.gov/pubmed/27747307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2016.04.004
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