Neuronal Na(+) Channels Are Integral Components of Pro-Arrhythmic Na(+)/Ca(2+) Signaling Nanodomain That Promotes Cardiac Arrhythmias During β-Adrenergic Stimulation

Although triggered arrhythmias including catecholaminergic polymorphic ventricular tachycardia (CPVT) are often caused by increased levels of circulating catecholamines, the mechanistic link between β-adrenergic receptor (AR) stimulation and the subcellular/molecular arrhythmogenic trigger(s) is unc...

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Veröffentlicht in:JACC Basic Transl Sci
Hauptverfasser: Radwański, Przemysław B., Ho, Hsiang-Ting, Veeraraghavan, Rengasayee, Brunello, Lucia, Liu, Bin, Belevych, Andriy E., Unudurthi, Sathya D., Makara, Michael A., Priori, Silvia G., Volpe, Pompeo, Armoundas, Antonis A., Dillmann, Wolfgang H., Knollmann, Bjorn C., Mohler, Peter J., Hund, Thomas J., Györke, Sándor
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2016
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PRE-CLINICAL RESEARCH
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5065245/
https://ncbi.nlm.nih.gov/pubmed/27747307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacbts.2016.04.004
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