Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT

AIMS: Cardiac calsequestrin (CASQ2) and histidine-rich Ca-binding protein (HRC) are sarcoplasmic reticulum (SR) Ca-binding proteins that regulate SR Ca release in mammalian heart. Deletion of either CASQ2 or HRC results in relatively mild phenotypes characterized by preserved cardiac structure and f...

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Vydáno v:Cardiovasc Res
Hlavní autoři: Liu, Bin, Ho, Hsiang-Ting, Brunello, Lucia, Unudurthi, Sathya D., Lou, Qing, Belevych, Andriy E., Qian, Lan, Kim, Do Han, Cho, Chunghee, Janssen, Paul M. L., Hund, Thomas J., Knollmann, Bjorn C., Kranias, Evangelia G., Györke, Sándor
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
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ORIGINAL ARTICLES
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614688/
https://ncbi.nlm.nih.gov/pubmed/26410369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvv222
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