RlmCD-mediated U747 methylation promotes efficient G748 methylation by methyltransferase RlmA(II) in 23S rRNA in Streptococcus pneumoniae; interplay between two rRNA methylations responsible for telithromycin susceptibility

Adenine at position 752 in a loop of helix 35 from positions 745 to 752 in domain II of 23S rRNA is involved in binding to the ribosome of telithromycin (TEL), a member of ketolides. Methylation of guanine at position 748 by the intrinsic methyltransferase RlmA(II) enhances binding of telithromycin...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Shoji, Tatsuma, Takaya, Akiko, Sato, Yoshiharu, Kimura, Satoshi, Suzuki, Tsutomu, Yamamoto, Tomoko
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605293/
https://ncbi.nlm.nih.gov/pubmed/26365244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv609
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