Crystal structure of RlmA(I): Implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site

The RlmA class of enzymes (RlmA(I) and RlmA(II)) catalyzes N1-methylation of a guanine base (G745 in Gram-negative and G748 in Gram-positive bacteria) of hairpin 35 of 23S rRNA. We have determined the crystal structure of Escherichia coli RlmA(I) at 2.8-Å resolution, providing 3D structure informati...

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Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Das, Kalyan, Acton, Thomas, Chiang, Yiwen, Shih, Lydia, Arnold, Eddy, Montelione, Gaetano T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2004
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC384692/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14999102/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0400189101
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