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Crystal structure of RlmA(I): Implications for understanding the 23S rRNA G745/G748-methylation at the macrolide antibiotic-binding site
The RlmA class of enzymes (RlmA(I) and RlmA(II)) catalyzes N1-methylation of a guanine base (G745 in Gram-negative and G748 in Gram-positive bacteria) of hairpin 35 of 23S rRNA. We have determined the crystal structure of Escherichia coli RlmA(I) at 2.8-Å resolution, providing 3D structure informati...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2004
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC384692/ https://ncbi.nlm.nih.gov/pubmed/14999102 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400189101 |
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