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Methylation of 23S rRNA Nucleotide G748 by RlmA(II) Methyltransferase Renders Streptococcus pneumoniae Telithromycin Susceptible

Several posttranscriptional modifications of bacterial rRNAs are important in determining antibiotic resistance or sensitivity. In all Gram-positive bacteria, dimethylation of nucleotide A2058, located in domain V of 23S rRNA, by the dimethyltransferase Erm(B) results in low susceptibility and resis...

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Detalhes bibliográficos
Main Authors: Takaya, Akiko, Sato, Yoshiharu, Shoji, Tatsuma, Yamamoto, Tomoko
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719731/
https://ncbi.nlm.nih.gov/pubmed/23716046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00164-13
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