VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis

Sterol 14α-demethylases (CYP51) are the enzymes essential for sterol biosynthesis. They serve as clinical targets for antifungal azoles and are considered as targets for treatment of human Trypanosomatidae infections. Recently, we have shown that VNI, a potent and selective inhibitor of trypanosomal...

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Bibliografiska uppgifter
I publikationen:J Infect Dis
Huvudupphovsmän: Lepesheva, Galina I., Hargrove, Tatiana Y., Rachakonda, Girish, Wawrzak, Zdzislaw, Pomel, Sébastien, Cojean, Sandrine, Nde, Pius N., Nes, W. David, Locuson, Charles W., Calcutt, M. Wade, Waterman, Michael R., Daniels, J. Scott, Loiseau, Philippe M., Villalta, Fernando
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2015
Ämnen:
Major Articles and Brief Reports
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601915/
https://ncbi.nlm.nih.gov/pubmed/25883390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv228
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