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Binding of a physiological substrate causes large-scale conformational reorganization in cytochrome P450 51
Sterol 14α-demethylases (CYP51s) are phylogenetically the most conserved cytochromes P450, and their three-step reaction is crucial for biosynthesis of sterols and serves as a leading target for clinical and agricultural antifungal agents. The structures of several (bacterial, protozoan, fungal, and...
Enregistré dans:
| Publié dans: | J Biol Chem |
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| Auteurs principaux: | , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2018
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6302162/ https://ncbi.nlm.nih.gov/pubmed/30327430 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005850 |
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