VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis

Sterol 14α-demethylases (CYP51) are the enzymes essential for sterol biosynthesis. They serve as clinical targets for antifungal azoles and are considered as targets for treatment of human Trypanosomatidae infections. Recently, we have shown that VNI, a potent and selective inhibitor of trypanosomal...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:J Infect Dis
मुख्य लेखकों: Lepesheva, Galina I., Hargrove, Tatiana Y., Rachakonda, Girish, Wawrzak, Zdzislaw, Pomel, Sébastien, Cojean, Sandrine, Nde, Pius N., Nes, W. David, Locuson, Charles W., Calcutt, M. Wade, Waterman, Michael R., Daniels, J. Scott, Loiseau, Philippe M., Villalta, Fernando
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2015
विषय:
Major Articles and Brief Reports
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601915/
https://ncbi.nlm.nih.gov/pubmed/25883390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv228
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