VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis

Sterol 14α-demethylases (CYP51) are the enzymes essential for sterol biosynthesis. They serve as clinical targets for antifungal azoles and are considered as targets for treatment of human Trypanosomatidae infections. Recently, we have shown that VNI, a potent and selective inhibitor of trypanosomal...

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Detalhes bibliográficos
Publicado no:J Infect Dis
Main Authors: Lepesheva, Galina I., Hargrove, Tatiana Y., Rachakonda, Girish, Wawrzak, Zdzislaw, Pomel, Sébastien, Cojean, Sandrine, Nde, Pius N., Nes, W. David, Locuson, Charles W., Calcutt, M. Wade, Waterman, Michael R., Daniels, J. Scott, Loiseau, Philippe M., Villalta, Fernando
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Major Articles and Brief Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4601915/
https://ncbi.nlm.nih.gov/pubmed/25883390
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/infdis/jiv228
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