Synthesis and study of new paramagnetic and diamagnetic verapamil derivatives

New derivatives of verapamil (1) modified with nitroxides and their precursors were synthesized and screened for reactive oxygen species (ROS) scavenging activities. The basic structure was modified by changing the nitrile group to an amide or the methyl substituent on tertiary nitrogen with nitroxi...

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Veröffentlicht in:Bioorg Med Chem
Hauptverfasser: Bognár, Balázs, Ahmed, Shabnam, Kuppusamy, M. Lakshmi, Selvendiran, Karuppaiyah, Khan, Mahmood, Jekő, József, Hankovszky, Olga H., Kálai, Tamás, Kuppusamy, Periannan, Hideg, Kálmán
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4596527/
https://ncbi.nlm.nih.gov/pubmed/20347319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.02.040
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