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GIMAP5 Deficiency Is Associated with Increased AKT Activity in T Lymphocytes

Long-term survival of T lymphocytes in quiescent state is essential to maintain their cell numbers in secondary lymphoid organs. In mice and in rats, the loss of functional GTPase of the immune associated nucleotide binding protein 5 (GIMAP5) causes peripheral T lymphopenia due to spontaneous death...

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Bibliographische Detailangaben
Veröffentlicht in:PLoS One
Hauptverfasser: Chen, Xi-Lin, Serrano, Daniel, Mayhue, Marian, Hoebe, Kasper, Ilangumaran, Subburaj, Ramanathan, Sheela
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4595448/
https://ncbi.nlm.nih.gov/pubmed/26440416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0139019
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