Phase II study of PX-866 in recurrent glioblastoma

BACKGROUND: Glioblastoma (GBM) is the most aggressive malignancy of the central nervous system in adults. Increased activity of the phosphatidylinositol-3-OH kinase (PI3K) signal transduction pathway is common. We performed a phase II study using PX-866, an oral PI3K inhibitor, in participants with...

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Vydáno v:Neuro Oncol
Hlavní autoři: Pitz, Marshall W., Eisenhauer, Elizabeth A., MacNeil, Mary V., Thiessen, Brian, Easaw, Jacob C., Macdonald, David R., Eisenstat, David D., Kakumanu, Ankineedu S., Salim, Muhammad, Chalchal, Haji, Squire, Jeremy, Tsao, Ming Sound, Kamel-Reid, Suzanne, Banerji, Shantanu, Tu, Dongsheng, Powers, Jean, Hausman, Diana F., Mason, Warren P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2015
Témata:
Clinical Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588751/
https://ncbi.nlm.nih.gov/pubmed/25605819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou365
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