Phase II study of PX-866 in recurrent glioblastoma

BACKGROUND: Glioblastoma (GBM) is the most aggressive malignancy of the central nervous system in adults. Increased activity of the phosphatidylinositol-3-OH kinase (PI3K) signal transduction pathway is common. We performed a phase II study using PX-866, an oral PI3K inhibitor, in participants with...

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Publicado en:Neuro Oncol
Autores principales: Pitz, Marshall W., Eisenhauer, Elizabeth A., MacNeil, Mary V., Thiessen, Brian, Easaw, Jacob C., Macdonald, David R., Eisenstat, David D., Kakumanu, Ankineedu S., Salim, Muhammad, Chalchal, Haji, Squire, Jeremy, Tsao, Ming Sound, Kamel-Reid, Suzanne, Banerji, Shantanu, Tu, Dongsheng, Powers, Jean, Hausman, Diana F., Mason, Warren P.
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2015
Materias:
Clinical Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588751/
https://ncbi.nlm.nih.gov/pubmed/25605819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou365
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