Phase II study of PX-866 in recurrent glioblastoma

BACKGROUND: Glioblastoma (GBM) is the most aggressive malignancy of the central nervous system in adults. Increased activity of the phosphatidylinositol-3-OH kinase (PI3K) signal transduction pathway is common. We performed a phase II study using PX-866, an oral PI3K inhibitor, in participants with...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Pitz, Marshall W., Eisenhauer, Elizabeth A., MacNeil, Mary V., Thiessen, Brian, Easaw, Jacob C., Macdonald, David R., Eisenstat, David D., Kakumanu, Ankineedu S., Salim, Muhammad, Chalchal, Haji, Squire, Jeremy, Tsao, Ming Sound, Kamel-Reid, Suzanne, Banerji, Shantanu, Tu, Dongsheng, Powers, Jean, Hausman, Diana F., Mason, Warren P.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Clinical Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588751/
https://ncbi.nlm.nih.gov/pubmed/25605819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou365
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