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Millisecond Dynamics of the Small Domain Generate the Kinetic Cooperativity Effect in Human Pancreatic Glucokinase

The hallmark of glucokinase (GCK), which catalyzes the phosphorylation of glucose during glycolysis, is its kinetic cooperativity whose understanding at atomic detail has remained open since its discovery over 40 years ago. Here, we show that the origin of kinetic cooperativity is rooted in intramol...

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Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Larion, Mioara, Hansen, Alexandar L., Zhang, Fengli, Bruschweiler-Li, Lei, Tugarinov, Vitali, Miller, Brian G., Brüschweiler, Rafael
Médium: Artigo
Jazyk:Inglês
Vydáno: 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587531/
https://ncbi.nlm.nih.gov/pubmed/26013420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201501204
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