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Dual allosteric activation mechanisms in monomeric human glucokinase

Cooperativity in human glucokinase (GCK), the body’s primary glucose sensor and a major determinant of glucose homeostatic diseases, is fundamentally different from textbook models of allostery because GCK is monomeric and contains only one glucose-binding site. Prior work has demonstrated that mill...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Whittington, A. Carl, Larion, Mioara, Bowler, Joseph M., Ramsey, Kristen M., Brüschweiler, Rafael, Miller, Brian G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577146/
https://ncbi.nlm.nih.gov/pubmed/26283387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506664112
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