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Dual allosteric activation mechanisms in monomeric human glucokinase
Cooperativity in human glucokinase (GCK), the body’s primary glucose sensor and a major determinant of glucose homeostatic diseases, is fundamentally different from textbook models of allostery because GCK is monomeric and contains only one glucose-binding site. Prior work has demonstrated that mill...
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4577146/ https://ncbi.nlm.nih.gov/pubmed/26283387 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1506664112 |
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