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Role of connecting loop I in catalysis and allosteric regulation of human glucokinase
Glucokinase (GCK, hexokinase IV) is a monomeric enzyme with a single glucose binding site that displays steady-state kinetic cooperativity, a functional characteristic that affords allosteric regulation of GCK activity. Structural evidence suggests that connecting loop I, comprised of residues 47–71...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Blackwell Publishing Ltd
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4088975/ https://ncbi.nlm.nih.gov/pubmed/24723372 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2473 |
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