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Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase

Glucokinase (GK) is a monomeric allosteric enzyme and plays a pivotal role in blood glucose homeostasis. GK is regulated by GK regulatory protein (GKRP), and indirectly by allosteric effectors of GKRP. Despite the critical roles of GK and GKRP, the molecular basis for the allosteric regulation mecha...

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Autors principals: Choi, Jung Min, Seo, Moon-Hyeong, Kyeong, Hyun-Ho, Kim, Eunkyung, Kim, Hak-Sung
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3690866/
https://ncbi.nlm.nih.gov/pubmed/23733961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1300457110
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