Millisecond Dynamics of the Small Domain Generate the Kinetic Cooperativity Effect in Human Pancreatic Glucokinase

The hallmark of glucokinase (GCK), which catalyzes the phosphorylation of glucose during glycolysis, is its kinetic cooperativity whose understanding at atomic detail has remained open since its discovery over 40 years ago. Here, we show that the origin of kinetic cooperativity is rooted in intramol...

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Detaylı Bibliyografya
Yayımlandı:Angew Chem Int Ed Engl
Asıl Yazarlar: Larion, Mioara, Hansen, Alexandar L., Zhang, Fengli, Bruschweiler-Li, Lei, Tugarinov, Vitali, Miller, Brian G., Brüschweiler, Rafael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4587531/
https://ncbi.nlm.nih.gov/pubmed/26013420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201501204
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