The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death

Deficiency of cyclin-dependent kinase 5 (Cdk5) has been linked to the death of postmitotic cortical neurons during brain development. We now report that, in mouse cortical neurons, Cdk5 is capable of phosphorylating the transcription factor FOXO1 at Ser249 in vitro and in vivo. Cellular stresses res...

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Udgivet i:J Neurosci
Main Authors: Zhou, Jiechao, Li, Huifang, Li, Xiaoping, Zhang, Guanyun, Niu, Yaqiong, Yuan, Zengqiang, Herrup, Karl, Zhang, Yun-Wu, Bu, Guojun, Xu, Huaxi, Zhang, Jie
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2015
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582140/
https://ncbi.nlm.nih.gov/pubmed/25673854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3051-14.2015
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