The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death

Deficiency of cyclin-dependent kinase 5 (Cdk5) has been linked to the death of postmitotic cortical neurons during brain development. We now report that, in mouse cortical neurons, Cdk5 is capable of phosphorylating the transcription factor FOXO1 at Ser249 in vitro and in vivo. Cellular stresses res...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Zhou, Jiechao, Li, Huifang, Li, Xiaoping, Zhang, Guanyun, Niu, Yaqiong, Yuan, Zengqiang, Herrup, Karl, Zhang, Yun-Wu, Bu, Guojun, Xu, Huaxi, Zhang, Jie
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2015
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582140/
https://ncbi.nlm.nih.gov/pubmed/25673854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3051-14.2015
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados