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The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death
Deficiency of cyclin-dependent kinase 5 (Cdk5) has been linked to the death of postmitotic cortical neurons during brain development. We now report that, in mouse cortical neurons, Cdk5 is capable of phosphorylating the transcription factor FOXO1 at Ser249 in vitro and in vivo. Cellular stresses res...
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| Pubblicato in: | J Neurosci |
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| Autori principali: | , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Society for Neuroscience
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4582140/ https://ncbi.nlm.nih.gov/pubmed/25673854 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3051-14.2015 |
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