The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death

Deficiency of cyclin-dependent kinase 5 (Cdk5) has been linked to the death of postmitotic cortical neurons during brain development. We now report that, in mouse cortical neurons, Cdk5 is capable of phosphorylating the transcription factor FOXO1 at Ser249 in vitro and in vivo. Cellular stresses res...

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Xehetasun bibliografikoak
Argitaratua izan da:J Neurosci
Egile Nagusiak: Zhou, Jiechao, Li, Huifang, Li, Xiaoping, Zhang, Guanyun, Niu, Yaqiong, Yuan, Zengqiang, Herrup, Karl, Zhang, Yun-Wu, Bu, Guojun, Xu, Huaxi, Zhang, Jie
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Society for Neuroscience 2015
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582140/
https://ncbi.nlm.nih.gov/pubmed/25673854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3051-14.2015
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