The Roles of Cdk5-Mediated Subcellular Localization of FOXO1 in Neuronal Death

Deficiency of cyclin-dependent kinase 5 (Cdk5) has been linked to the death of postmitotic cortical neurons during brain development. We now report that, in mouse cortical neurons, Cdk5 is capable of phosphorylating the transcription factor FOXO1 at Ser249 in vitro and in vivo. Cellular stresses res...

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Publicado en:J Neurosci
Autores principales: Zhou, Jiechao, Li, Huifang, Li, Xiaoping, Zhang, Guanyun, Niu, Yaqiong, Yuan, Zengqiang, Herrup, Karl, Zhang, Yun-Wu, Bu, Guojun, Xu, Huaxi, Zhang, Jie
Formato: Artigo
Lenguaje:Inglês
Publicado: Society for Neuroscience 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582140/
https://ncbi.nlm.nih.gov/pubmed/25673854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3051-14.2015
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