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Cdk5 Nuclear Localization Is p27-dependent in Nerve Cells: IMPLICATIONS FOR CELL CYCLE SUPPRESSION AND CASPASE-3 ACTIVATION

Initiation of a cell cycle in an adult neuron leads to cell death, placing great importance on the mechanisms that normally suppress the neuronal cell cycle. We have previously shown that the cyclin-dependent kinase Cdk5 is an important part of this process, but only when it is present in the nucleu...

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Detalhes bibliográficos
Main Authors: Zhang, Jie, Li, Huifang, Herrup, Karl
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859566/
https://ncbi.nlm.nih.gov/pubmed/20189989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.068262
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