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Replication fork progression during re-replication requires the DNA damage checkpoint and double-strand break repair
Replication origins are under tight regulation to ensure activation occurs only once per cell cycle [1, 2]. Origin re-firing in a single S-phase leads to the generation of DNA double-strand breaks (DSBs) and activation of the DNA damage checkpoint [2–7]. If the checkpoint is blocked, cells enter mit...
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| Опубликовано в: : | Curr Biol |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4580973/ https://ncbi.nlm.nih.gov/pubmed/26051888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2015.04.058 |
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