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Replication fork progression during re-replication requires the DNA damage checkpoint and double-strand break repair

Replication origins are under tight regulation to ensure activation occurs only once per cell cycle [1, 2]. Origin re-firing in a single S-phase leads to the generation of DNA double-strand breaks (DSBs) and activation of the DNA damage checkpoint [2–7]. If the checkpoint is blocked, cells enter mit...

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Bibliografski detalji
Izdano u:Curr Biol
Glavni autori: Alexander, Jessica L., Barrasa, M. Inmaculada, Orr-Weaver, Terry L.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580973/
https://ncbi.nlm.nih.gov/pubmed/26051888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2015.04.058
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