MCL-1 Depletion Impairs DNA Double-Strand Break Repair and Reinitiation of Stalled DNA Replication Forks

Myeloid cell leukemia 1 (MCL-1) is a prosurvival BCL-2 protein family member highly expressed in hematopoietic stem cells (HSCs) and regulated by growth factor signals that manifest antiapoptotic activity. Here we report that depletion of MCL-1 but not its isoform MCL-1S increases genomic instabilit...

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Publicado en:Mol Cell Biol
Main Authors: Mattoo, Abid R., Pandita, Raj K., Chakraborty, Sharmistha, Charaka, Vijaya, Mujoo, Kalpana, Hunt, Clayton R., Pandita, Tej K.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2017
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5247612/
https://ncbi.nlm.nih.gov/pubmed/27821478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00535-16
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