SMARCAD1 Phosphorylation and Ubiquitination Are Required for Resection during DNA Double-Strand Break Repair

The chromatin remodeling factor SMARCAD1, an SWI/SNF ATPase family member, has a role in 5′ end resection at DNA double-strand breaks (DSBs) to produce single-strand DNA (ssDNA), a critical step for subsequent checkpoint and repair factor loading to remove DNA damage. However, the mechanistic detail...

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Veröffentlicht in:iScience
Hauptverfasser: Chakraborty, Sharmistha, Pandita, Raj K., Hambarde, Shashank, Mattoo, Abid R., Charaka, Vijaya, Ahmed, Kazi M., Iyer, Swaminathan P., Hunt, Clayton R., Pandita, Tej K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5993204/
https://ncbi.nlm.nih.gov/pubmed/29888761
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2018.03.016
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