β2-spectrin depletion impairs DNA damage repair

β2-Spectrin (β2SP/SPTBN1, gene SPTBN1) is a key TGF-β/SMAD3/4 adaptor and transcriptional cofactor that regulates TGF-β signaling and can contribute to liver cancer development. Here we report that cells deficient in β2-Spectrin (β2SP) are moderately sensitive to ionizing radiation (IR) and extremel...

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Udgivet i:Oncotarget
Main Authors: Horikoshi, Nobuo, Pandita, Raj K., Mujoo, Kalpana, Hambarde, Shashank, Sharma, Dharmendra, Mattoo, Abid R., Chakraborty, Sharmistha, Charaka, Vijaya, Hunt, Clayton R., Pandita, Tej K.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Priority Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085102/
https://ncbi.nlm.nih.gov/pubmed/27248179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.9677
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