Lamin A/C Depletion Enhances DNA Damage-Induced Stalled Replication Fork Arrest

The human LMNA gene encodes the essential nuclear envelope proteins lamin A and C (lamin A/C). Mutations in LMNA result in altered nuclear morphology, but how this impacts the mechanisms that maintain genomic stability is unclear. Here, we report that lamin A/C-deficient cells have a normal response...

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主要な著者: Singh, Mayank, Hunt, Clayton R., Pandita, Raj K., Kumar, Rakesh, Yang, Chin-Rang, Horikoshi, Nobuo, Bachoo, Robert, Serag, Sara, Story, Michael D., Shay, Jerry W., Powell, Simon N., Gupta, Arun, Jeffery, Jessie, Pandita, Shruti, Chen, Benjamin P. C., Deckbar, Dorothee, Löbrich, Markus, Yang, Qin, Khanna, Kum Kum, Worman, Howard J., Pandita, Tej K.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2013
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Articles
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592031/
https://ncbi.nlm.nih.gov/pubmed/23319047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01676-12
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