Lamin A/C Depletion Enhances DNA Damage-Induced Stalled Replication Fork Arrest

The human LMNA gene encodes the essential nuclear envelope proteins lamin A and C (lamin A/C). Mutations in LMNA result in altered nuclear morphology, but how this impacts the mechanisms that maintain genomic stability is unclear. Here, we report that lamin A/C-deficient cells have a normal response...

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Detalhes bibliográficos
Main Authors: Singh, Mayank, Hunt, Clayton R., Pandita, Raj K., Kumar, Rakesh, Yang, Chin-Rang, Horikoshi, Nobuo, Bachoo, Robert, Serag, Sara, Story, Michael D., Shay, Jerry W., Powell, Simon N., Gupta, Arun, Jeffery, Jessie, Pandita, Shruti, Chen, Benjamin P. C., Deckbar, Dorothee, Löbrich, Markus, Yang, Qin, Khanna, Kum Kum, Worman, Howard J., Pandita, Tej K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3592031/
https://ncbi.nlm.nih.gov/pubmed/23319047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01676-12
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