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Replication fork progression during re-replication requires the DNA damage checkpoint and double-strand break repair
Replication origins are under tight regulation to ensure activation occurs only once per cell cycle [1, 2]. Origin re-firing in a single S-phase leads to the generation of DNA double-strand breaks (DSBs) and activation of the DNA damage checkpoint [2–7]. If the checkpoint is blocked, cells enter mit...
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| Publicado no: | Curr Biol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4580973/ https://ncbi.nlm.nih.gov/pubmed/26051888 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cub.2015.04.058 |
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