Farnesoid X Receptor Inhibits Glucagon-Like Peptide-1 Production by Enteroendocrine L-cells

Bile acids (BA) are signalling molecules which activate the transmembrane receptor TGR5 and the nuclear receptor FXR. BA sequestrants (BAS) complex BA in the intestinal lumen and decrease intestinal FXR activity. The BAS-BA complex also induces Glucagon-Like Peptide-1 (GLP-1) production by L-cells w...

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Publicado no:Nat Commun
Main Authors: TRABELSI, Mohamed-Sami, DAOUDI, Mehdi, PRAWITT, Janne, DUCASTEL, Sarah, TOUCHE, Véronique, SAYIN, Sama I., PERINO, Alessia, BRIGHTON, Cheryl A., SEBTI, Yasmine, KLUZA, Jérôme, BRIAND, Olivier, DEHONDT, Hélène, VALLEZ, Emmanuelle, DORCHIES, Emilie, BAUD, Grégory, SPINELLI, Valeria, HENNUYER, Nathalie, CARON, Sandrine, BANTUBUNGI, Kadiombo, CAIAZZO, Robert, REIMANN, Frank, MARCHETTI, Philippe, LEFEBVRE, Philippe, BÄCKHED, Fredrik, GRIBBLE, Fiona M., SCHOONJANS, Kristina, PATTOU, François, TAILLEUX, Anne, STAELS, Bart, LESTAVEL, Sophie
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579574/
https://ncbi.nlm.nih.gov/pubmed/26134028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8629
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