Farnesoid X Receptor Inhibits Glucagon-Like Peptide-1 Production by Enteroendocrine L-cells

Bile acids (BA) are signalling molecules which activate the transmembrane receptor TGR5 and the nuclear receptor FXR. BA sequestrants (BAS) complex BA in the intestinal lumen and decrease intestinal FXR activity. The BAS-BA complex also induces Glucagon-Like Peptide-1 (GLP-1) production by L-cells w...

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Pubblicato in:Nat Commun
Autori principali: TRABELSI, Mohamed-Sami, DAOUDI, Mehdi, PRAWITT, Janne, DUCASTEL, Sarah, TOUCHE, Véronique, SAYIN, Sama I., PERINO, Alessia, BRIGHTON, Cheryl A., SEBTI, Yasmine, KLUZA, Jérôme, BRIAND, Olivier, DEHONDT, Hélène, VALLEZ, Emmanuelle, DORCHIES, Emilie, BAUD, Grégory, SPINELLI, Valeria, HENNUYER, Nathalie, CARON, Sandrine, BANTUBUNGI, Kadiombo, CAIAZZO, Robert, REIMANN, Frank, MARCHETTI, Philippe, LEFEBVRE, Philippe, BÄCKHED, Fredrik, GRIBBLE, Fiona M., SCHOONJANS, Kristina, PATTOU, François, TAILLEUX, Anne, STAELS, Bart, LESTAVEL, Sophie
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579574/
https://ncbi.nlm.nih.gov/pubmed/26134028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8629
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