CDKN2A/p16INK4a suppresses hepatic fatty acid oxidation through the AMPKα2-SIRT1-PPARα signaling pathway

In addition to their well-known role in the control of cellular proliferation and cancer, cell cycle regulators are increasingly identified as important metabolic modulators. Several GWAS have identified SNPs near CDKN2A, the locus encoding for p16INK4a (p16), associated with elevated risk for cardi...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Deleye, Yann, Cotte, Alexia Karen, Hannou, Sarah Anissa, Hennuyer, Nathalie, Bernard, Lucie, Derudas, Bruno, Caron, Sandrine, Legry, Vanessa, Vallez, Emmanuelle, Dorchies, Emilie, Martin, Nathalie, Lancel, Steve, Annicotte, Jean Sébastien, Bantubungi, Kadiombo, Pourtier, Albin, Raverdy, Violeta, Pattou, François, Lefebvre, Philippe, Abbadie, Corinne, Staels, Bart, Haas, Joel T., Paumelle, Réjane
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2020
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863903/
https://ncbi.nlm.nih.gov/pubmed/33037071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.012543
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