PPARα blocks glucocorticoid receptor α-mediated transactivation but cooperates with the activated glucocorticoid receptor α for transrepression on NF-κB

Glucocorticoid receptor α (GRα) and peroxisome proliferator-activated receptor α (PPARα) are transcription factors with clinically important immune-modulating properties. Either receptor can inhibit cytokine gene expression, mainly through interference with nuclear factor κB (NF-κB)-driven gene expr...

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Main Authors: Bougarne, Nadia, Paumelle, Réjane, Caron, Sandrine, Hennuyer, Nathalie, Mansouri, Roxane, Gervois, Philippe, Staels, Bart, Haegeman, Guy, De Bosscher, Karolien
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2678648/
https://ncbi.nlm.nih.gov/pubmed/19376972
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0806742106
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