Glucocorticoid Receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor

The transcriptional activity of the glucocorticoid receptor (GR) is co-determined by its ability to recruit a vast and varying number of cofactors. We here identify Striatin-3 (STRN3) as a novel interaction partner of GR that interferes with GR’s ligand-dependent transactivation capacity. Remarkably...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Petta, Ioanna, Bougarne, Nadia, Vandewalle, Jolien, Dejager, Lien, Vandevyver, Sofie, Ballegeer, Marlies, Desmet, Sofie, Thommis, Jonathan, De Cauwer, Lode, Lievens, Sam, Libert, Claude, Tavernier, Jan, De Bosscher, Karolien
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567040/
https://ncbi.nlm.nih.gov/pubmed/28827617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09246-6
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