Mechanisms Underlying the Functional Cooperation Between PPARα and GRα to Attenuate Inflammatory Responses

Glucocorticoids (GCs) act via the glucocorticoid receptor (NR3C1, GRα) to combat overshooting responses to infectious stimuli, including lipopolysaccharide (LPS). As such, GCs inhibit the activity of downstream effector cytokines, such as tumor necrosis factor (TNF). PPARα (NR1C1) is a nuclear recep...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Bougarne, Nadia, Mylka, Viacheslav, Ratman, Dariusz, Beck, Ilse M., Thommis, Jonathan, De Cauwer, Lode, Tavernier, Jan, Staels, Bart, Libert, Claude, De Bosscher, Karolien
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6695567/
https://ncbi.nlm.nih.gov/pubmed/31447832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01769
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