Mechanisms Underlying the Functional Cooperation Between PPARα and GRα to Attenuate Inflammatory Responses

Glucocorticoids (GCs) act via the glucocorticoid receptor (NR3C1, GRα) to combat overshooting responses to infectious stimuli, including lipopolysaccharide (LPS). As such, GCs inhibit the activity of downstream effector cytokines, such as tumor necrosis factor (TNF). PPARα (NR1C1) is a nuclear recep...

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Dades bibliogràfiques
Publicat a:Front Immunol
Autors principals: Bougarne, Nadia, Mylka, Viacheslav, Ratman, Dariusz, Beck, Ilse M., Thommis, Jonathan, De Cauwer, Lode, Tavernier, Jan, Staels, Bart, Libert, Claude, De Bosscher, Karolien
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6695567/
https://ncbi.nlm.nih.gov/pubmed/31447832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.01769
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