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p16(INK4a) deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages
The CDKN2A locus, which contains the tumor suppressor gene p16(INK4a), is associated with an increased risk of age-related inflammatory diseases, such as cardiovascular disease and type 2 diabetes, in which macrophages play a crucial role. Monocytes can polarize towards classically (CAMφ) or alterna...
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| Główni autorzy: | , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Język: | Inglês |
| Wydane: |
American Society of Hematology
2011
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| Hasła przedmiotowe: | |
| Dostęp online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3677739/ https://ncbi.nlm.nih.gov/pubmed/21636855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-10-313106 |
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