p16(INK4a) deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages

The CDKN2A locus, which contains the tumor suppressor gene p16(INK4a), is associated with an increased risk of age-related inflammatory diseases, such as cardiovascular disease and type 2 diabetes, in which macrophages play a crucial role. Monocytes can polarize towards classically (CAMφ) or alterna...

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Autores principales: Cudejko, Céline, Wouters, Kristiaan, Fuentes, Lucía, Hannou, Sarah Anissa, Paquet, Charlotte, Bantubungi, Kadiombo, Bouchaert, Emmanuel, Vanhoutte, Jonathan, Fleury, Sébastien, Remy, Patrick, Tailleux, Anne, Chinetti, Giulia, Dombrowicz, David, Staels, Bart, Paumelle, Réjane
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677739/
https://ncbi.nlm.nih.gov/pubmed/21636855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-10-313106
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