The nuclear receptor FXR inhibits Glucagon-Like Peptide-1 secretion in response to microbiota-derived Short-Chain Fatty Acids

The gut microbiota participates in the control of energy homeostasis partly through fermentation of dietary fibers hence producing short-chain fatty acids (SCFAs), which in turn promote the secretion of the incretin Glucagon-Like Peptide-1 (GLP-1) by binding to the SCFA receptors FFAR2 and FFAR3 on...

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Publicado no:Sci Rep
Main Authors: Ducastel, Sarah, Touche, Véronique, Trabelsi, Mohamed-Sami, Boulinguiez, Alexis, Butruille, Laura, Nawrot, Margaux, Peschard, Simon, Chávez-Talavera, Oscar, Dorchies, Emilie, Vallez, Emmanuelle, Annicotte, Jean-Sébastien, Lancel, Steve, Briand, Olivier, Bantubungi, Kadiombo, Caron, Sandrine, Bindels, Laure B., Delzenne, Nathalie M., Tailleux, Anne, Staels, Bart, Lestavel, Sophie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6957696/
https://ncbi.nlm.nih.gov/pubmed/31932631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56743-x
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