Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity

OBJECTIVE: Bile acids (BA) participate in the maintenance of metabolic homeostasis acting through different signaling pathways. The nuclear BA receptor farnesoid X receptor (FXR) regulates pathways in BA, lipid, glucose, and energy metabolism, which become dysregulated in obesity. However, the role...

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Main Authors: Prawitt, Janne, Abdelkarim, Mouaadh, Stroeve, Johanna H.M., Popescu, Iuliana, Duez, Helene, Velagapudi, Vidya R., Dumont, Julie, Bouchaert, Emmanuel, van Dijk, Theo H., Lucas, Anthony, Dorchies, Emilie, Daoudi, Mehdi, Lestavel, Sophie, Gonzalez, Frank J., Oresic, Matej, Cariou, Bertrand, Kuipers, Folkert, Caron, Sandrine, Staels, Bart
Format: Artigo
Sprog:Inglês
Udgivet: American Diabetes Association 2011
Fag:
Metabolism
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121443/
https://ncbi.nlm.nih.gov/pubmed/21593203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0030
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