Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity

OBJECTIVE: Bile acids (BA) participate in the maintenance of metabolic homeostasis acting through different signaling pathways. The nuclear BA receptor farnesoid X receptor (FXR) regulates pathways in BA, lipid, glucose, and energy metabolism, which become dysregulated in obesity. However, the role...

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Hlavní autoři: Prawitt, Janne, Abdelkarim, Mouaadh, Stroeve, Johanna H.M., Popescu, Iuliana, Duez, Helene, Velagapudi, Vidya R., Dumont, Julie, Bouchaert, Emmanuel, van Dijk, Theo H., Lucas, Anthony, Dorchies, Emilie, Daoudi, Mehdi, Lestavel, Sophie, Gonzalez, Frank J., Oresic, Matej, Cariou, Bertrand, Kuipers, Folkert, Caron, Sandrine, Staels, Bart
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2011
Témata:
Metabolism
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3121443/
https://ncbi.nlm.nih.gov/pubmed/21593203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0030
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