Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart

In the postischemic heart, coronary vasodilation is impaired due to loss of endothelial nitric oxide synthase (eNOS) function. Although the eNOS cofactor tetrahydrobiopterin (BH(4)) is depleted, its repletion only partially restores eNOS-mediated coronary vasodilation, indicating that other critical...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Reyes, Levy A., Boslett, James, Varadharaj, Saradhadevi, De Pascali, Francesco, Hemann, Craig, Druhan, Lawrence J., Ambrosio, Giuseppe, El-Mahdy, Mohamed, Zweier, Jay L.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2015
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577172/
https://ncbi.nlm.nih.gov/pubmed/26297248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505556112
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