Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart

In the postischemic heart, coronary vasodilation is impaired due to loss of endothelial nitric oxide synthase (eNOS) function. Although the eNOS cofactor tetrahydrobiopterin (BH(4)) is depleted, its repletion only partially restores eNOS-mediated coronary vasodilation, indicating that other critical...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Reyes, Levy A., Boslett, James, Varadharaj, Saradhadevi, De Pascali, Francesco, Hemann, Craig, Druhan, Lawrence J., Ambrosio, Giuseppe, El-Mahdy, Mohamed, Zweier, Jay L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577172/
https://ncbi.nlm.nih.gov/pubmed/26297248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505556112
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