HPLC analysis of tetrahydrobiopterin and its pteridine derivatives using sequential electrochemical and fluorimetric detection: application to tetrahydrobiopterin autoxidation and chemical oxidation

Tetrahydrobiopterin (BH(4)) is an essential cofactor of endothelial nitric oxide (NO) synthase and when depleted, endothelial dysfunction results with decreased production of NO. BH(4) is also an anti-oxidant being a good “scavenger” of oxidative species. NADPH oxidase, xanthine oxidase, and mitocho...

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Detalhes bibliográficos
Main Authors: Biondi, Roberto, Ambrosio, Giuseppe, De Pascali, Francesco, Tritto, Isabella, Capodicasa, Enrico, Druhan, Lawrence J., Hemann, Craig, Zweier, Jay L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3307828/
https://ncbi.nlm.nih.gov/pubmed/22286026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2012.01.010
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