Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart

In the postischemic heart, coronary vasodilation is impaired due to loss of endothelial nitric oxide synthase (eNOS) function. Although the eNOS cofactor tetrahydrobiopterin (BH(4)) is depleted, its repletion only partially restores eNOS-mediated coronary vasodilation, indicating that other critical...

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Bibliografski detalji
Izdano u:Proc Natl Acad Sci U S A
Glavni autori: Reyes, Levy A., Boslett, James, Varadharaj, Saradhadevi, De Pascali, Francesco, Hemann, Craig, Druhan, Lawrence J., Ambrosio, Giuseppe, El-Mahdy, Mohamed, Zweier, Jay L.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2015
Teme:
Biological Sciences
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577172/
https://ncbi.nlm.nih.gov/pubmed/26297248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1505556112
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