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Inhibition of CD38 with the Thiazoloquin(az)olin(on)e 78c Protects the Heart against Postischemic Injury

Inhibition of and genetic deletion of the NAD(P)(+) hydrolase [NAD(P)ase] CD38 have been shown to protect against ischemia/reperfusion (I/R) injury in rat and mouse hearts. CD38 has been shown to enhance salvage of NADP(H), which in turn prevents impairment of endothelial nitric oxide synthase funct...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Boslett, James, Reddy, Nikhil, Alzarie, Yasmin A., Zweier, Jay L.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413770/
https://ncbi.nlm.nih.gov/pubmed/30635470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.254557
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