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Genetic deletion of CD38 confers post-ischemic myocardial protection through preserved pyridine nucleotides
Following the onset of ischemia/reperfusion (I/R), CD38 activation occurs and is associated with depletion of NAD(P)(H) in the heart as well as myocardial injury and endothelial dysfunction. Studies with pharmacological inhibitors suggest that the NADP(+)-hydrolyzing ability of CD38 can deplete the...
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| Publicado en: | J Mol Cell Cardiol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6699759/ https://ncbi.nlm.nih.gov/pubmed/29476764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2018.02.015 |
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