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Genetic deletion of CD38 confers post-ischemic myocardial protection through preserved pyridine nucleotides

Following the onset of ischemia/reperfusion (I/R), CD38 activation occurs and is associated with depletion of NAD(P)(H) in the heart as well as myocardial injury and endothelial dysfunction. Studies with pharmacological inhibitors suggest that the NADP(+)-hydrolyzing ability of CD38 can deplete the...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Boslett, James, Helal, Moustafa, Chini, Eduardo, Zweier, Jay L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699759/
https://ncbi.nlm.nih.gov/pubmed/29476764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2018.02.015
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